Piperacillin and Tazobactam Injection

Piperacillin & Tazobactam Injection refers to the ‘Antibiotics’ kind of drugs, primarily used to treat bacterial infections. The composition contains two medications namely: Piperacillin and Tazobactam.  Piperacillin refers to the group of penicillin antibiotics. It has bactericidal activity against gram-negative and gram-positive and aerobic and anaerobic bacteria. Piperacillin acts by binding to the penicillin-binding proteins inside the bacterial cell wall and inhibits its cell wall synthesis.

Tazobactam is a beta-lactamase inhibitor. Beta-lactamases are the enzymes produced by bacteria to gain multi-resistance to β-lactam antibiotics, such as cephalosporins and penicillins. Tazobactam is used to treat the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In Piperacillin & Tazobactam Injection, Tazobactam works by preventing bacteria from destroying Piperacillin.

Uses of Piperacillin & Tazobactam Injection

• Bacterial infections
• Hospital-acquired
• Ventilator-associated pneumonia
• Urinary tract infections
• Intra-abdominal infections
• Skin and soft tissue infections
• Uterine infections

Medical Benefits

• Binding to the penicillin-binding proteins inside the bacterial cell wall inhibits its cell wall synthesis.
• prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms.
• works by preventing bacteria from destroying Piperacillin.
• helps treat various bacterial infections of the stomach, lungs, skin, and uterus.

Direction For Use

• Piperacillin & Tazobactam Injections should be administered by a healthcare professional.
• Do not self-administer.
• Gently squeeze the skin with one hand and quickly
• Insert the needle straight into the muscle.
• Pull back the plunger; if blood is seen in the syringe, remove the needle from the skin.
• Change the needle to a clean one of the same size.
• It is alright to use the drug already in the syringe.
• Inject the drug slowly.

Storage

• Store in a cool place
• Store in a dry place
• Stay away from sunlight

Side Effects

• Nausea
• Trouble sleeping
• Constipation
• Diarrhea
• Headache

Precaution

Discuss the following health conditions with your healthcare professional before taking this medication.

• This medication should not be taken if you are breastfeeding.
• You are not advised to drink alcohol while using this medication.
• Do not drive or operate machinery.
• If you have a liver impairment or any concerns consult your, doctor
• Consult your doctor, if you have kidney impairment or any concerns.

Frequently Asked Questions

In which conditions should I stay cautious while using Piperacillin & Tazobactam Injections?

Piperacillin & Tazobactam Injections should be used with proper caution and doctor consultation if you have any cystic fibrosis, kidney disease, fits, colitis, bleeding disorders, heart or liver diseases, and undergoing dialysis.

I am undergoing vaccination for typhoid this week, can I use Piperacillin & Tazobactam Injections?

Piperacillin & Tazobactam Injections can affect live vaccines like typhoid vaccines and reduce their effectiveness.